Abstract: 1,1-Bis(silyloxy)ketene acetals represent useful synthetic building blocks which can be regarded as masked carboxylic acid dianions. In recent years, a number of cyclization reactions of 1,1-bis(silyloxy)ketene acetals have been reported which provide a convenient synthesis of various pharmacologically relevant heterocyclic products.

Review: Synlett 2012, 23, 1283-1290.

Period of investigation: 2005 - 2008

Keywords: silyl enol ethers; heterocycles; cyclizations