Abstract: Domino reactions of chromones with activated carbonyl compounds, such as dimethyl acetone-1,3-dicarboxylate and 1,3-diphenylacetone, and with 1,3-bis(silyloxy)-1,3-butadienes, electroneutral equivalents of 1,3-dicarbonyl dianions, allow for a convenient synthesis of a great variety of products. The regioselectivity and course of the reaction depends on the substituent located at carbon C3 of the chromone moiety and also on the type of nucleophile employed.

Review: Peter Langer, Beilstein J. Org. Chem. 2024, 20, 1256-1269.

Period of investigation: 2002 - Today

Keywords: domino reactions; chromones; 1,3-dicarbonyl compounds