Abstract: A variety of domino and multicomponent reactions were developed which include domino Knoevenagel / hetero-Diels-Alder reactions, the combination of Knoevenagel reactions with [3+2] cycloadditions of nitrogen ylides, domino Knoevenagel / enamine cyclization reactions, formal [3+3] cyclizations of pyridinium salts, [3+3] cyclizations of thioxindoles with fluoroaroyl chlorides, cyclizations of heterocyclic enamines with diimines and triazines, domino [4+2] / retro [4+2] reactions, formal [3+3] cyclizations of 2-ethynylpyridines with enones, reaction of trifluoromethyl-substituted 1,3-diketones with lithiated alkynes and formal [3+2] cyclizations of 2,3-dihalopyridines with imines. These reactions provide a convenient access to various drug-like compounds.

Review: Peter Langer, Eur. J. Org. Chem. 2024, 27, e202400153 (account).

Period of investigation: 2009 - Today

Keywords: domino reactions; cyclizations; iminium salts