In the project, the influence of biophysical stimulation on chondrogenic differentiation will be investigated in an animal model. Cell-seeded hydrogels and collagen scaffolds will be electro-mechanically stimulated ex vivo and subsequently implanted in a chondral defect model of the rabbit knee. Afterwards, the repair and the viscoelastic behaviour of regenerated articular cartilage tissue will be evaluated. Furthermore, tissue-specific differentiation and intercellular signalling pathways will be analysed in vitro in multifunctional osteochondral scaffolds by application of biophysical stimulation. In addition, research on an electrostimulative implant system for the in situ treatment of osteochondral lesions will be performed with regard to design, electric field simulation and experimental validation.

A01 / A01 / A03 / A04 / A05 / B01 / B02 / B03 / C01 / C03 / S01 / INF

Electrical and mechanical stimulation of cartilage

Prof. Dr. med. habil. Dipl.-Ing. Rainer Bader
E-Mail
Tel.: +49 381 494 9337

Prof. Dr.-Ing. Hermann Seitz
E-Mail
Tel.: +49 381 498 9090

PD Dr. rer. hum. habil. Anika Jonitz-Heincke
E-Mail
Tel.: +49 381 494 9306

Rostock University Medical Center
Department of Orthopaedics
Doberaner Straße 142
18057 Rostock

University of Rostock
Chair of Mikrofluidics
Justus-von-Liebig Weg 6
18059 Rostock

Nada Abroug
Vivica Freiin Grote
Mario Jackszis
Dr. rer. nat. Marco Stubbe
Dr. rer. hum. Janine Waletzko-Hellwig

Pedram Azizi
Dr. med. Sina Gräber
Prof. Dr. med. Christoph Lutter
Alexander Riess
Zezhong Song
Martin Stephan
Prof. Dr. Thomas Tischer

Dr. rer. hum. Simone Krüger
Dr.-Ing. Roland Matzmohr
Dr. rer. hum. Franziska Sahm
Mareike Specht
Dr.-Ing. Alina Weizel