Abstract: The cyclization of bis(silyl enol ethers) with iminium salts (derived, for example, from pyridine, quinoline, isoquinoline, quinoxaline, quinazoline, pyrazine, quinoxaline, and 2,5-dimethoxypyrrolidines) allows an efficient synthesis of various bridged and non-bridged N-heterobicyclic products which are of pharmacological relevance.

Review: Eur. J. Org. Chem. 2007, 2233-2238.

Period of investigation: 2004 – 2008

Keywords: silyl enol ether; cyclizations; heterocycles; iminium salts