Abstract: 2-Isothiocyanatobenzonitrile (ITCB) and isocyanatobenzonitrile (ICB) represent versatile synthetic building blocks containing a nitrile and an isothiocyanate or an isocyanate function, respectively. Domino reactions of ITCB and ICB provide a convenient access to a variety of pharmacologically important heterocycles.

Review: Curr. Org. Chem. 2009, 13, 955-964.

Period of investigation: 2002 – 2009

Keywords: domino reactions; cyclizations; heterocycles